Levetiracetam, also known as Keppra, is an anti-seizure medication utilized by veterinarians to treat animals suffering from refractory seizure disorders. Levetiracetam is often used with phenobarbital when phenobarbital alone does not provide adequate benefits.
Side effects range from sedation and staggering in dogs and reduced appetite, hypersalivation, and lethargy in cats. Changes in behavior and gastrointestinal effects could occur. Other side effects may occur. If you notice anything unusual, contact your veterinarian.
Dogs and Cats
The liver does not extensively metabolize levetiracetam, which makes it safe for use in patients suffering from pre-existing liver diseases.
Levetiracetam should be given orally as directed by your veterinarian.
This medication does not have an FDA approved indication for use in animals, but it is a common and acceptable practice for veterinarians to prescribe this human medication for use in animals. Dose adjustments may be required in patients with pre-existing kidney disease. Use with caution in pregnant, breeding, or nursing animals.
Make sure to tell your veterinarian what other medication you are giving to your pet. Quite often your veterinarian may prescribe two different medications, and a drug interaction may be anticipated. The following drugs can potentially interact with levetiracetam: NSAIDS, phenobarbital (may require dose adjustments). In this case, your veterinarian may vary the dose and/or monitor your pet more closely. Contact your veterinarian if your animal experiences any unusual reactions when different medications are given together.
Allergic reactions to medications may occur. Be sure to inform VetSource and your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.