Loperamide

By Lifelearn Inc.

Medications

December 8, 2008

Why has my veterinarian prescribed this medicine?

Loperamide is used to help manage diarrhea in dogs. It helps stop diarrhea by slowing down motility (movement) in the intestines. Loperamide has also been used to treat acute colitis and malabsorption/maldigestion.

How do I give this medication?

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  • Give this medication to your pet as directed by your veterinarian. READ THE LABEL CAREFULLY.
  • If the medicine is a liquid, shake well before using and measure the dose with reasonable care.
  • Try to give this medication at about the same time each day.
  • DO NOT give the pet more medicine than directed and do not give more often than directed.
  • Try not to miss giving any doses.

What if I miss giving a dose?

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give the pet two doses at once.

How do I store this medicine?

  • Keep this medicine out of reach of children.
  • Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight.
  • Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.

What are the potential side effects?

"If given long term, this medication may lead to constipation."
  • There are few reported side effects with this medication.
  • The following side effects have been reported: vomiting, soft stools, bloody diarrhea, weight loss.
  • If given long term, this medication may lead to constipation.
  • Dogs that have a mutation in the multi-drug resistance gene (MDR gene), may lack p-glycoprotein in the blood-brain barrier. with these animals, loperamide may cause profound sedation. Susceptible breeds include: Collie, Australian shepherds, Old English sheepdogs, longhaired Whippets and Shetland sheepdogs.
  • Contact your veterinarian if the diarrhea persists.
  • Other side effects may occur. If you notice anything unusual, contact your veterinarian.

Are there any possible drug interactions?

  • Make sure to tell your veterinarian what other medication you are giving to your pet.
  • Quite often your veterinarian may prescribe two different medications, and sometimes a drug interaction may be anticipated. In this case, your veterinarian may vary the dose and/or monitor your pet more closely.
  • Loperamide should not be given with ketoconazole or other MDR1 membrane inhibitors. These medications may increase blood-brain barrier penetration and cause depression.
  • Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

REMEMBER!  READ THE LABEL.

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