Papers & Book Chapters Authored
Diagnosis and Treatment of a Feline Oral Mast Cell Tumor
Abstract: A cat was diagnosed with an oral mast cell tumor following incisional biopsy. The location of the tumor, possible metastasis, financial restraint and patient disposition severely limited therapeutic options. The patient was treated with six doses of 1-(2-chloroethyl)3-cyclohexyl-1-nitrosurea (CCNU) and methylprednisolone acetate. Complete remission was obtained after the third dosing regimen. This is the first documented case of feline oral mast cell tumor and one of a small group of cats with various cancers to be responsive to CCNU treatment.
Authored: Wright ZM, Chretin J
Published: J Fel Med Surg 2006; 8:285-289
Measurement of Urinary Canine S100A8/A9 and S100A12 Concentrations as Candidate Biomarkers of Lower Urinary Tract Neoplasia in Dogs
Abstract: Members of the S100 family of calcium-binding proteins (S100A8, A9, and A12; calgranulins) have been associated with inflammation and cancer in human beings. Proteins S100A8 and A9 were overexpressed in human patients with transitional cell carcinoma (TCC) and prostate carcinoma (PCA), suggesting their potential as biomarkers for diagnosing and/or predicting the progression of such neoplasms.
Authored: Heilmann RM, Wright ZM, Lanerie DJ, Suchodolski JS, Steiner JM
Published: Journal of Veterinary Diagnostic Investigation. 2014; 26: 104-112
The Use, Publication and Future Directions of Immunocytochemistry in Veterinary Medicine: A Consensus of the Oncology-Pathology Working Group
Abstract: One of the primary objectives of the Oncology Pathology Working Group (OPWG), a joint initiative of the Veterinary Cancer Society and the American College of Veterinary Pathologists, is for oncologists and pathologists to collaboratively generate consensus documents to standardize aspects of and provide guidelines for oncologic pathology.
Authored: Priest HL, Hume KR, Killick D, Kozicki A, Rizzo VL, Seeling D, Snyder LA, Springer NL, Wright ZM, Robat C
Published: Vet and Comp Onco 2016; 15:3
Retrospective Evaluation of Toceranib Phosphate (Palladia®) Toxicity in Cats
Abstract: The purpose of this study was to describe the toxicity profile of toceranib phosphate in tumour bearing cats. Medical records were reviewed from seven institutions.
Authored: Merrick CH, Pierro JA, Saba CF, Northrup NC, Schleiss SE, Sones EA, Wright ZW, Regan RC, Siedliecki CT, Bergman PJ
Published: Vet and Comp Onco 2016; 15:3
Geographical Differences in Survival of Dogs With non-Hodgkin Lymphoma Treated With a CHOP Based Chemotherapy Protocol
Abstract: The purpose of this study was to determine if a geographic difference in progression free survival exists for dogs with lymphoma treated within the US.
Authored: H. Wilson-Robles, C.M. Budke, T. Miller, N. Dervisis, A. Novosad, Z. Wright, D. Thamm, K. Vickery, K. Burgess, M. Childress, J. Lori, C. Saba, S. Rau, M. Silver, G. Post, K. Reeds, S. Gillings, S. Schleis, T. Stein, B. Brugmann, C. DeRegis, O. Smrkovski, J. Lawrence, and T. Laver
Published: Vet and Comp Onco. 2017; 15:4
Concurrent Use of Rabacfosadine and L-asparaginase for Relapsed or Refractory Multicentric Lymphoma in Dogs
Abstract: To evaluate the safety and efficacy of L-ASP given concurrently with RAB in dogs with relapsed multicentric lymphoma.
Authored: Cawley J, Wright Z, Meleo K, Post G, Clifford C, Vickery K, Vail D, Bergman P, Thamm D
Published: JVIM 2020
Rabacfosadine for Naïve Lymphoma: Efficacy and Adverse Event Profile Across Three Studies
Authored: Saba CF, Clifford CA, Burgess KE, Phillips BS, Vail DM, Wright ZM, Curran KM, Fan TM, Elmslie RS, Post GS, Thamm DH
Published: Accepted for publication in Vet and Comp Onco.
Survival Data for Canine Oral Extramedullary Plasmacytomas: A Retrospective Analysis (1996-2006)
Abstract: In a 10-year period, extramedullary plasmacytomas (EMP) represented 5.2% of all oral tumors found in the dog (16/302). These 16 oral EMP comprised 28.5% of all EMP within the same time period. Eleven dogs died with a median survival time of 474 days. Five dogs remain alive at the time of this writing. Dogs without complete surgical removal of the EMP and no adjuvant therapy had a median survival time of 138 days. Oral EMP have a clinical behavior consistent with EMP arising from other tissues. They have no obvious correlation with multiple myeloma, and complete surgical resection may be curative.
Authored: Wright ZM, Rogers KS, Mansell J
Published: J Am Anim Hosp Assoc 2008; 44: 75-81
MicroRNA Expression in Canine Mammary Cancer
Abstract: MicroRNAs (miRNAs) are 18-22-nt noncoding RNAs that are involved in post-transcriptional regulation of genes. Oncomirs, a subclass of miRNAs, include genes whose expression, or lack thereof, are associated with cancers. Until the last decade, the domestic dog was an underused model for the study of various human diseases that have genetic components. The dog exhibits marked genetic and physiologic similarity to the human, thereby making it an excellent model for study and treatment of various hereditary diseases.
Authored: Boggs RM, Wright ZM, Stickney M, Porter WW, Murphy KE
Published: Mammalian Genome 2008; 19: 561-569
A Pilot Study Evaluating Changes in Pancreatic Lipase Immunoreactivity Concentrations in Canines Treated With L-asparaginase (ASNase), Vincristine, or Both for Lymphoma
Abstract: L-asparaginase (ASNase) is a common chemotherapy agent for the treatment of lymphoid malignancies. L-asparaginase has been reported to cause clinical pancreatitis in both humans and canines.
Authored: Wright ZM, Steiner JM, Suchodolski JS, Rogers KS, Barton CL, Brown MR
Published: Canadian J Vet Research. 2009; 73: 103-110
Prevalence and Prognostic Impact of Hypocobalaminaemia in Dogs with Lymphoma
Abstract: To determine the prevalence of hypocobalaminemia in dogs with multicentric lymphoma and to investigate any relationship between serum cobalamin concentration and disease outcome.
Authored: Cook AK, Wright ZM, Suchodolski JS, Brown MR, Steiner JS
Published: J Am Vet Med Assoc 2009; 235: 1437-1441
Carboplatin Chemotherapy in a Cat With a Recurrent Anal Sac Apocrine Gland Adenocarcinoma
Abstract: An 8-year-old, castrated male, domestic shorthaired cat was presented for evaluation of a perianal mass. The mass was incompletely excised, and histological assessment resulted in a diagnosis of anal sac adenocarcinoma. The cat had a partial response to carboplatin therapy but a short overall duration of response. Necropsy confirmed the original diagnosis as well as metastasis to the regional lymph nodes and lungs.
Authored: Wright ZM, Fryer JS, Calise D, Oliveira F
Published: J Am Anim Hosp Assoc 2010; 46: 66-69
Apparent Feline Leukemia Virus-Induced Chronic Lymphocytic Leukemia and Response to Treatment
Abstract: Chylothorax secondary to chronic lymphocytic leukemia (CLL) was diagnosed in a feline leukemia virus (FeLV)-positive 8-year-old castrated male domestic shorthair feline. The leukemia resolved following therapy with chlorambucil, prednisone, cyclophosphamide, doxorubicin, and lomustine. To our knowledge, this is the first reported case of CLL in an FeLV-positive cat. Although a causative relationship cannot be proven, patients diagnosed with either disease may benefit from diagnostics to rule out the presence of the other concurrent condition.
Authored: Kyle K, Wright ZM
Published: J Fel Med Surg. 2010; 12: 341-344
The Use of Urethral Stents in Small Animal Veterinary Medicine
Authored: Wright ZM
Published: Consulta de Difucion Veterinaria. 2011; special volume: 212-214
Survival of Dogs Treated with Various Radiation Protocols for Intranasal Sarcomas
Authored: Sones E, Smith A, Schlies S, Brawner W, Almond G, Taylor K, Wypij J, Hamilton T, Arthur J, Keyerleber M, Lawrence J, Cadile C, Wright Z
Published: Vet Rad and Ultrasound. 2013; 54 (2). 194-201
Book Chapters
Wright ZM, Rogers KS. Facilitating client grief. In Consultations in Feline Internal Medicine 6th Edition. Eds: August JA. Elsevier publishing. 2009.
Wright ZM. Mast Cell Neoplasias. In Clinical Small Animal Internal Medicine. 1st Ed: Bruyette, D. Wylie publishing, 2020.
Abstracts
U Tress, JM Steiner, MD Miller, ZM Wright, CG Ruaux, and DA Williams. Intra-individual variation in fecal IgA concentration of dogs. Gastrointestinal Laboratory, College of Veterinary Medicine, Texas A&M University, College Station, TX. 2003.
Steiner JM, Ruaux CG, Miller MD, Wright ZM, Teague SR, Vaden S, and Williams DA. Intra-individual variability of fecal A1-proteinase inhibitor concentration in clinically healthy dogs. J Vet Int Med; 17: 445, 2003.
Wright ZM, Steiner J, Rogers KS. Incidence of subclinical pancreatitis after L-Asparaginase administration in dogs with lymphoma. 26th Veterinary Cancer Society Annual Conference. Pine Mountain, GA, October 2006.
Cook AK, Wright ZM, Suchodolski JS, Brown MR, Steiner JS. Prevalence and prognostic impact of hypocobalaminaemia in dogs with lymphoma. British Small Animal Veterinary Association Annual Conference. Birmingham, England, April 2008.
R.M. Heilmann, Z.M. Wright, D.J. Lanerie, J.S. Suchodolski, J.M. Steiner. Urinary Canine Calprotectin Concentrations in Dogs with Transitional Cell Carcinoma. Gastrointestinal Laboratory, Texas A&M University, College Station, TX, USA. ECVIM 2010.
Sones E, Smith A, Schlies S, Brawner W, Almond G, Taylor K, Wypij J, Hamilton T, Arthur J, Keyerleber M, Lawrence J, Cadile C, Wright Z. Survival of Dogs Treated with Various Radiation Protocols for Intranasal Sarcomas. 30th Veterinary Cancer Society Annual Conference. San Diego, CA, October 2010.
Wilson-Robles H, Budke A, Miller T, Novosad A, Wright Z, Dervisis N, Thamm D, Vickery K, Burgess K, Childress M. Geographic Differences in Disease Free Interval and Survival Times for Canines with Lymphoma in the USA. 32nd Veterinary Cancer Society Annual Conference. Las Vegas, NV. October 2012.
Sutton M, Conway E, Martinez S, Wright Z, Schrempp D, Wilson-Robles H. Adjunctive intra-incisional treatment of incompletely resected canine soft tissue sarcomas with 5-fluorouracil. 35th Veterinary Cancer Society Annual Conference. Vienna, VA, October 2015.
Bergman, Philip; Wright, Zachary; Roof, Erin; Sheafor, Sarah; Hofer, Jennifer; Schrempp, Diane; Kitchell, Barbara; Elpiner, Amanda; Hazzah, Trina; Chretin, Johnny; Sahora-Andrews, Alexandra; Loop, Stephanie; Mills, Tracy; Evans, Elizabeth; Hennessy, Kris; Thomson, Duncan. Pilot study of Regeneus KVAX autologous cancer vaccine and limb amputation for dogs with appendicular osteosarcoma. 36th Veterinary Cancer Society Annual Conference. Orlando, FL. October 2016.
Bergman, Philip; Sheafor, Sarah; Wilson, Mary; Tran, Darcel; Wright, Zachary; Gill, Virginia; Shor, Sharon; Tu, Chantal; Atwater, Stephen; Kidd, Jason; Siedlecki, Cecile; Tansey-Baldwin, Colleen; Elpiner, Amanda; Ettinger, Susan; Koshino, Akiko; Loop, Stephanie; Guzzo, Jessica; Mills, Tracy Retrospective Analysis of Oncept® Use In Canine Malignant Melanoma: The VCA experience in 320 dogs (2007-Present). 36th Veterinary Cancer Society Annual Conference. Orlando, FL. October 2016.