What is emodepside/praziquantel?
Emodepside/praziquantel (brand name Profender®), is a topical (spot-on) antiparasitic drug used to treat and control hookworms, roundworms, and tapeworms in cats and kittens that are at least 8 weeks of age and weigh at least 1 kg (2.2 lb).
It is used “off label” or “extra label” to treat certain parasitic infections in some reptile species and in rabbits. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions carefully.
How do I give my pet emodepside/praziquantel?
Emodepside/praziquantel comes in topical solution form.
- Topical solutions are applied directly onto the skin. Part the fur at the base of the head and apply the product directly to visible skin.
- Do not apply to broken skin or wet fur.
- Do not allow the cat or any other animals to lick or groom the application site for 1 hour after application.
- Do not allow this medication to touch the eyes or mouth.
- Humans should avoid direct contact with the application site for 24 hours after this medication is applied.
This medication will take effect in about 1 to 2 days. This medication needs to be given monthly to protect against internal parasites.
What if I miss giving my pet the medication?
Give the missed dose as soon as you remember and then wait the recommended time as prescribed by your veterinarian for the next dose. Do not give the pet two doses at once.
Are there any potential side effects from emodepside/praziquantel?
Emodepside with praziquantel may cause the following side effects:
- licking or excessive grooming
- scratching or fur loss at application site
- drooling
- lack of energy or agitation
- vomiting
The following reactions are rare, but if they occur, contact your veterinarian immediately:
- an allergic reaction such as irregular breathing, rash, fever, or puffiness and swelling around the face
Emodepside can also cause neurologic toxicity in cats with two copies of the MDR1 mutation. Signs may include:
- unsteady gait (ataxia)
- drooling
- tremors
- weakness and/or partial paralysis
- coma
- seizures
- death
Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.
Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.
Are there any risk factors for this medication?
This medication should be used with CAUTION in cats who:
- are sick or weak
- are pregnant, nursing, or used for breeding
- are less than 8 weeks of age and/or less than 2.4 lb (1.1 kg)
- have tested positive for heartworm
- are known to have two copies of the MDR1 mutation
Are there any drug interactions I should be aware of?
Certain medications should be USED WITH CAUTION when given with emodepside/praziquantel, including but not limited to:
- P-glycoprotein substrates or inhibitors (e.g., cyclosporine, prednisolone, ivermectin)
- CYP34A inducers (e.g., dexamethasone, phenobarbital)
- CYP34A inhibitors (e.g., itraconazole, ketoconazole)
Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.
Is any monitoring needed with this medication?
Your veterinarian may schedule follow-up visits for monitoring. In this case, follow your veterinarian’s directions.
How do I store emodepside/praziquantel?
- Store at or below room temperature.
- Protect from freezing.
- Keep medication out of reach of children and pets.
What should I do in case of emergency?
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.
