By Lauren Forsythe, PharmD, DICVP; Rania Gollakner, BS, DVM, MPH

What is grapiprant?

Grapiprant (brand name: Galliprant®) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis pain and inflammation in dogs.

How is grapiprant given?

  • Grapiprant is given by mouth in the form of a tablet.
  • Give with or without food; however, absorption is best on an empty stomach.
  • If vomiting occurs when given on an empty stomach, give the next dose with food or a treat.

This medication will take effect quickly, in about 1 to 2 hours, and improvement in clinical signs should follow.

What if I miss giving my pet the medication?

If you miss a dose, give it when you remember. However, if it is close to the time for the next dose, skip the dose you missed, give it at the next scheduled time, and return to the regular dosing schedule. Never give your pet two doses at once or give extra doses.

Are there any potential side effects?

Grapiprant can have MILD TO SEVERE SIDE EFFECTS including:

  • vomiting and diarrhea
  • low appetite
  • blood or mucous in the stool
  • decreases in blood protein levels

Never give grapiprant prescribed for one dog in your household to another pet without first consulting your veterinarian. Grapiprant is not approved or recommended for use in cats. This moderate-acting medication should stop working in a few days, although effects can be longer in pets with liver or kidney disease.

Are there any risk factors for this medication?

Grapiprant SHOULD NOT BE USED in dogs that:

  • are allergic to it
  • are younger than 9 months old
  • weigh less than 8 pounds
  • are breeding, pregnant, or nursing 
  • have severe heart disease
  • are currently taking other NSAIDs or corticosteroids

Grapiprant should be USED WITH CAUTION in dogs that have a history of a sulfonamide drug allergy.

Are there any drug interactions I should be aware of?

Certain medications may interact with grapiprant and so it is important to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your dog is taking before starting any new treatments, including:

  • other NSAIDs
  • corticosteroids (e.g., prednisone, dexamethasone)

Is any monitoring needed with this medication?

  • Your veterinarian will perform baseline bloodwork and urinalysis before your pet starts grapiprant.
  • If your dog is taking grapiprant for extended periods (as in the treatment of osteoarthritis), your veterinarian will do periodic blood tests to check liver and kidney function. It is important to attend these follow-up appointments. 
  • Your veterinarian may recommend recheck examinations to ensure the medication is working adequately to manage pain.
  • At home, monitor for any side effects such as those noted above. If any side effects occur, discontinue the medication and contact your veterinarian. 

How do I store grapiprant?

  • Grapiprant should be stored at room temperature below 86°F (30°C) and protected from light.
  • Keep the container out of reach of children and pets.
  • Ensure grapiprant is stored in a tightly closed container and secured inside a cabinet to prevent accidental ingestion. These chewable tablets can be very tempting to dogs.
  • Store compounded forms of this medication according to the label.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

Related Articles