What is lufenuron?
Lufenuron (brand name Program®) is an insect growth regulator that controls flea infestations in dogs, cats, rabbits, and ferrets. It is frequently found in combination with other medications such as milbemycin and/or praziquantel (brand names: Sentinel®, Spectrum®).
Lufenuron works as a growth inhibitor: an adult flea must feed on a treated animal to ingest the drug, and any eggs produced by this adult will not survive. It does not kill adult fleas, nor does it repel fleas. Because the effects target offspring, the overall flea control effects can take several months. Therefore, this medication works better in combination with other products for long-term control as opposed to a sole therapy.
How is lufenuron given?
- Lufenuron is given by mouth in the form of a tablet or liquid. It can also be given as an injection in the hospital or clinic setting to cats only.
- Give oral forms with food, either by mixing it into the food or giving it directly after a meal.
- If it is mixed into food and the pet does not consume the entire dose, re-dose with the full, recommended dose as soon as possible.
- All cats and dogs in a household must be treated with a flea control product concurrently to control flea populations in the household.
- Treatment should begin several weeks before flea season and end several weeks after flea season. If fleas are active year-round, then treatment should continue without stopping.
This medication can take up to a few weeks before full effects are noted; however, effects may not be noted outwardly.
What if I miss giving my pet the medication?
If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. For example, if you forgot to give your pet their dose on June 1 and remember on June 18, give the dose on June 18 and resume your dosing schedule starting on July 1. Contact your veterinarian if you are concerned about a missed dose.
Are there any potential side effects?
Lufenuron may cause the following side effects:
- vomiting
- diarrhea
- lack of appetite
- tiredness
- reddening of the skin
- itchiness
- a small lump at the injection site that should resolve in a few weeks (if injected form is given)
Serious side effects are rare, but may include:
- hives
- severe skin rashes
- difficulty breathing
This long-acting medication may last up to 4–6 weeks and may last longer in pets with kidney or liver disease.
Are there any risk factors for this medication?
- Lufenuron should NOT BE USED in pets that are allergic to it.
- Lufenuron should be USED WITH CAUTION in pets less than 6 weeks of age.
This medication is considered safe in pregnant, breeding, and lactating pets.
Are there any drug interactions I should be aware of?
There are no drug interactions reported at this time. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.
Is any monitoring needed with this medication?
- No specific monitoring is required while your pet is taking this medication.
- Your veterinarian may monitor your pet to be sure that the medication is working.
How do I store lufenuron?
Store at room temperature between 59°F and 77°F (15°C and 25°C). Exposure to temperatures outside this range for less than 48 hours should not affect the medication.
What should I do in case of emergency?
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.
