Cutaneous Lymphoma in Cats

Tammy Hunter, DVM; Malcolm Weir, DVM, MSc, MPH; Robin Downing, DVM, DAAPM, DACVSMR, CVPP, CRPP

What is cutaneous lymphoma?

Lymphoma is a type of cancer that is common in cats and can be seen in almost every organ. Cutaneous lymphoma is a rare form that occurs in the skin. Less than 2% of lymphoma cases in cats occur in the skin. 

Feline cutaneous lymphoma can present various clinical signs, including itching, alopecia (hair loss), scaly skin, skin redness, loss of skin color, ulcers, nodules, pustules, and plaques. 

As cutaneous lymphoma progresses, the skin becomes thickened, reddened, ulcerated, and may ooze fluid. While any skin area may be affected, the most common locations to find cutaneous lymphoma lesions include the junction between mucus membranes and the skin. Examples include the lip margins, eyelids, around the nose, anus/rectum, vulva, and the prepuce of the penis. 

How is cutaneous lymphoma diagnosed? 

Cutaneous lymphoma is diagnosed by skin biopsy, which is the removal of affected tissue to be examined by a veterinary pathologist in a laboratory. It may spread to lymph nodes in the area of the skin lesions, which is the disease’s pathway to the rest of the body. Once the lymph nodes are involved, systemic spread to the organs can occur. 

Is there any treatment for feline cutaneous lymphoma? 

Unfortunately, feline cutaneous lymphoma is considered incurable. Surgical removal can be attempted for solitary lesions, although the tumor often returns to the area or has already spread elsewhere in the body. Palliative chemotherapy or radiation therapy may slow progression and contribute to survival time. Supportive care using antibiotics is important for treating concurrent skin infections. 

What is the outlook for cats with cutaneous lymphoma? 

This condition comes with a grave prognosis. On average, cats diagnosed with cutaneous lymphoma and given treatment will live only 6–12 months. This disease is complex and discouraging for both cats and their owners.

© Copyright 2025 LifeLearn Inc. This content was written by LifeLearn Animal Health (LifeLearn Inc.) and is licensed to this practice for the personal use of its clients. Copying, printing, or further distributing this material is prohibited without LifeLearn’s express written consent. The use of artificial intelligence or automated tools to rewrite, republish, adapt, or repurpose this content, in whole or in part, is prohibited and does not create any ownership or derivative rights. This content does not contain all available information about medications and has not been reviewed by the FDA’s Center for Veterinary Medicine or Health Canada’s Veterinary Drugs Directorate. This content is not a substitute for medical advice or a proper clinical examination. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Last updated on Apr 17, 2025.

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