By Lifelearn Inc.


Why has my veterinarian prescribed this medicine?

Mitotane is primarily used to treat Cushing's disease in dogs. It has also been used to treat adrenal tumors. Mitotane reduces the amount of cortisone-like hormones produced by the adrenal cortex. These steroids are important for various body functions; however excessive levels of these hormones can cause problems.

How do I give this medication?

"Pregnant women should not handle this medication."
  • Give this medication to your pet as directed by your veterinarian. READ THE LABEL CAREFULLY.
  • If the medicine is a liquid, measure the dose with reasonable care.
  • Give this medication with food - preferably an oily or fatty food. Food increases the oral absorption of the medication.
  • Try to give this medication at about the same time each day.
  • DO NOT give the pet more medicine than directed and do not give more often than directed.
  • DO NOT stop giving this medication to your pet unless directed by your veterinarian. Call your veterinarian ahead of time if your pet needs a refill.
  • Try not to miss giving any doses.
  • The person administering the drug should wash their hands after handling the medication.
  • Pregnant women should not handle this medication.

What if I miss giving a dose?

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give the pet two doses at once.

How do I store this medicine?

  • Keep this medicine out of reach of children.
  • Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight.
  • Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.

What are the potential side effects?

  • Your pet may experience the following side effects: drowsiness, nausea, vomiting, diarrhea and a loss of appetite.
  • Other side effects may occur. If you notice anything unusual, contact your veterinarian.

Are there any possible drug interactions?

  • Make sure to tell your veterinarian what other medication you are giving to your pet.
  • Quite often, your veterinarian may prescribe two different medications, and sometimes a drug interaction may be anticipated. In this case, your veterinarian may vary the dose and/or monitor your pet more closely.
  • The following drugs can potentially interact with mitotane: spironolactone, barbiturates, warfarin, insulin, and CNS depressants.
  • Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

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