Nystatin Combination - Topical

By Rania Gollakner, BS, DVM, MPH

What is nystatin combination?

Nystatin combination (brand names: Panalog®, Cortalone®, Animax®, Derma-vet®, Quadritop®, Dermalog®, Dermalone®, EnteDerm®, Resortin®) is a topical anti-yeast medication in combination with other medications, such as steroids or antibiotics, and it is used to treat skin lesions.

Depending on the product and how it is used, its use in cats, dogs, or other mammals to treat inflammatory skin conditions may be ‘off label’ or ‘extra label’. Many drugs are commonly prescribed for off label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully as their direction may be significantly different from those on the label.

How is nystatin combination given?

Nystatin combination is applied topically to the skin on the affected area. If necessary, trim the hair to allow the medication to reach the lesion. Do not allow your pet to lick or chew the treated area for at least 30 minutes after application. Wear gloves when applying this medication and wash hands after application. Avoid contact with eyes, nose, or mouth.

This medication should take effect within 1 to 2 hours, and while effects may not be visibly obvious, gradual improvements are usually noticeable after a few days.

What if I miss giving my pet the medication?

If you miss a dose, give it when you remember, but if it is close to the time for the next dose, skip the dose you missed and give it at the next scheduled time, and return to the regular dosing schedule. Never give your pet two doses at once or give extra doses.

Are there any potential side effects?

Side effects are uncommon but may include localized skin inflammation. Serious side effects include loss of appetite, vomiting, diarrhea, sudden hearing loss, worsening ear pain, head tilt, mouth sores, worsening lesions, increased thirst, more frequent urination, skin thinning, worsening hair loss, or new infections at the application site.

This moderate-acting medication should stop working in a few days, although effects can be longer in pets with liver or kidney disease.

Are there any risk factors for this medication?

Nystatin combination should not be used on pets that are allergic to it or in pets that have tuberculosis infections of the skin or a ruptured ear drum. It should be used cautiously in pets that require a large treatment area or in pets that are of a smaller in size. Nystatin combination should be used cautiously in pets with recurring ear infections. Do not use combinations that include corticosteroids on pets that are pregnant.

Are there any drug interactions I should be aware of?

There are no specific drug to drug interactions with nystatin combinations. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.

This medication, when combined with a corticosteroid, may interact with allergy testing; discontinue its use 2 weeks prior to allergy testing.

Is there any monitoring that needs to be done with this medication?

There is no specific monitoring that needs to be done while your pet is using this medication. Your veterinarian may monitor your pet to be sure that the medication is working. Monitor your pet at home for serious side effects.

How do I store nystatin combination?

Store in the original container at room temperature below 86°F (30°C) and away from light.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

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