Selamectin + Sarolaner Topical

By Krista Williams, BSc, DVM, CCRP

What is selamectin + sarolaner topical?

The combination of selamectin and sarolaner (Revolution Plus) is used to prevent heartworms and intestinal parasites (hookworms and roundworms), kill and prevent flea infestations, and treats tick infestation (Gulf Coast tick, American dog tick, and deer tick) in cats eight weeks and older. It is also used to treat and control ear mites.

It may also be used “off-label” for the treatment of Demodex mites (demodicosis). Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully as their directions may be significantly different from those on the label.

How is selamectin + sarolaner given?

This combination is applied to the skin on the back of the neck. Once applied to the skin, avoid massaging the medication into the skin or touching the application site while it is wet. Cats should not be bathed within the first 24 hours of application.

What if I miss giving a dose to my pet?

Give the dose as soon as you remember and start a new monthly dosing schedule. For example, if you forgot to give your pet his/her dose on June 1st and remember on June 18th, give the dose on June 18th and start a new monthly schedule. The next dose your pet will receive would be on July 18th. Do not give your pet two doses at once. Contact your veterinarian if you are concerned about a missed dose.

Are there any potential side effects?

When used as directed in cats, side effects are uncommon but may include lethargy, vomiting, skin lesions, diarrhea, itching, anorexia (no appetite), conjunctivitis, and sneezing. Accidental ingestion may cause decreased appetite, vomiting, soft stool, and salivation.

Sarolaner belongs to a class of drugs called isoxazolines. These drugs have been associated with neurologic side effects, such as tremors, ataxia (wobbly gait), and seizures. Contact your veterinarian if you observe these side effects. 1

This long-acting medication is designed to last for at least four weeks. However, negative side effects are usually short-lived if they occur at all.

Are there any risk factors for this medication?

Use cautiously in animals with low body fat (sick or very young), as they are more prone to side effects. As sarolaner is an isoxazoline, this medication should be used cautiously in cats with neurologic conditions, including seizures. Safety in breeding, pregnant, or nursing animals has not been established.

Are there any drug interactions I should be aware of?

There are no known drug interactions but be sure your veterinarian is aware of any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.

Is there any monitoring that needs to be done with this medication?

There is no specific monitoring that needs to be done while your pet is taking this medication; however, your veterinarian may recommend testing your cat for heartworm prior to beginning treatment as well as routine heartworm testing to be sure that the medication is working.

How do I store selamectin + sarolaner?

This combination should be stored in its original packaging at or below 86°F (30°C).

What should I do in case of an emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

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