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Early Stage Testing for Kidney Disease in Dogs

By Malcolm Weir, DVM, MSc, MPH; Kristiina Ruotsalo, DVM, DVSc, Dip ACVP; Margo S. Tant BSc, DVM, DVSc

Diagnosis, Pet Services

What is microalbuminuria?

Albumin is an important protein that is found in large quantities in the blood but is not normally present in the urine of healthy dogs. The term microalbuminuria refers to the presence of very small amounts of albumin in urine.

Microalbuminuria may indicate underlying health problems, and is sometimes an early warning sign of primary kidney disease (also known as renal disease).

What sorts of conditions result in microalbuminuria?

Many conditions can potentially lead to microalbuminuria. These include inflammatory conditions (e.g., dental disease, chronic skin disease, bowel inflammation, etc.), infectious disease (e.g., heartworm infection, Lyme disease, ehrlichiosis, etc.), metabolic disorders (e.g., diabetes mellitus, overactive adrenal glands), hypertension (high blood pressure), and cancer.

What is the ERD test for microalbuminuria and when should it be used?

The early renal damage test (ERD) is a simple rapid test that detects microalbuminuria. It is a better test than the routine urine “dipstick” test (see handout “Urinalysis”) for detecting small amounts of protein in urine.

The ERD test is used when the routine urine test for protein is negative and your veterinarian wants to:

  • look further for traces of protein in the urine. For example, in a dog at high risk for kidney disease.
  • do a comprehensive health screen to detect hidden illness in a dog.

The ERD should not be done when:

  • a routine urine test is positive for protein. In this situation, there is clearly excess protein in the urine and an ERD test will not provide any additional information. Your veterinarian may suggest doing a protein:creatinine ratio test, which is the best test to do when larger amounts of protein are present in the urine. See handout “Urine Protein:Creatinine Ratios” for more information.
  • there are obvious signs of inflammation, infection, or bleeding in the urinary system. The large amount of inflammatory protein in the urine would give a falsely high reading on the ERD.


What sample is needed to do the ERD test for microalbuminuria?

All that is needed is a small amount of urine collected in a sterile container. The sample can be stored in the refrigerator for up to 24 hours, but your veterinarian may want to collect fresh urine from your dog for the test.


If my dog has microalbuminuria, does this mean my pet has progressive renal disease?

No. In fact, the majority of dogs with microalbuminuria will not develop kidney disease.

"In most cases, correction or management of the underlying health problem will make the the microalbuminuria disappear."

In most cases, treatment or management of the underlying health problem will make the microalbuminuria disappear. It is only in a small percentage of dogs that microalbuminuria is truly a warning sign of early kidney disease. These dogs may go on to develop serious kidney disease and possibly kidney failure. Although a complete cure may not be possible, specific steps, such as a prescription diet and medication, can be taken to slow down the progression of the disease.

If my dog has microalbuminuria, what is the next step?

If microalbuminuria is detected, your veterinarian will likely recommend further testing to look for hidden disease. The choice of tests may vary but could include routine blood tests and urinalysis (see handouts “Complete Blood Count”, “Serum Biochemistry”, and “Urinalysis” for more information on these tests). If there is no evidence of underlying illness, then regular check-ups every 3-6 months including ERD testing may be recommended to monitor your dog’s health status and to watch for any change in microalbuminuria.

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