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Enilconazole

By Rania Gollakner, BS, DVM, MPH

Medications

What is enilconazole?

Enilconazole (brand name: Imaverol®) is a skin medication used to treat dermatophytosis (ringworm). Enilconazole is currently not available in the United States.

Its use in cats to treat dermatophytosis is ‘off label’ or ‘extra label’. Many drugs are commonly prescribed for off label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully as their directions may be significantly different from those on the label.

How is enilconazole given?

Enilconazole is given topically in the form of a wash/dip. Mix one part of the 10% concentrate with 50 parts lukewarm water to create a 0.2% dilute mixture. Dogs with long hair should be clipped prior to treatment. Remove crusts with a brush soaked in the diluted mixture, and then wash with the diluted mixture, taking care to rub the mixture thoroughly in the opposite direction of hair growth.

Avoid contact with your eyes or your pet’s eyes. Wear gloves while applying and consider wearing eye protection. If mixture comes into contact with your skin, wash your skin generously with soap and water.

What if I miss a scheduled bath?

Give the missed bath/dip as soon as you remember, and then wait the recommended amount of time between baths/dips. Never give extra baths/dips.

Are there any potential side effects?

This medication is well tolerated and side effects of the diluted emulsion are uncommon. The diluted emulsion is not irritating to the skin or eyes. Side effects in cats have been reported, including drooling, vomiting, lack of appetite, weight loss, muscle weakness, and elevated liver enzymes, however information regarding its use in cats is lacking.

There is no information (or studies) on how long this product lasts on the pet, but because enilconazole is not absorbed by the skin and is safe if ingested at dilute concentrations, its duration of effectiveness is not of concern.

Are there any risk factors for this medication?

Enilconazole should be used cautiously in cats as its safety has not been established. It should also be used cautiously in pregnant or lactating pets, although use is likely safe.

Are there any drug interactions I should be aware of?

There are no specific drug interactions with enilconazole. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.

Is there any monitoring that needs to be done with this medication?

There is no specific monitoring that needs to be done while your pet is using this medication. Your veterinarian may monitor your pet to be sure that the medication is working.

How do I store enilconazole?

Store at room temperature (below 77°F or 25°C) and protect from light. Dispose the unused portions of the diluted solutions. The concentrated solution should be used within 3 months of opening the bottle.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

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