Moxidectin + Fluralaner Topical

By Krista Williams, BSc, DVM, CCRP

What is moxidectin + fluralaner?

Moxidectin topical is a topical avermectin antiparasitic that is used to prevent heartworms and treat intestinal parasites (hookworms and roundworms). Fluralaner is used to treat and prevent fleas and also kills black-legged ticks (deer ticks). These two drugs are combined as one medication (Bravecto® Plus, Vitrecto®) for use in cats.

Its use in cats to treat skin and ear mites, and other ticks is “off-label”. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully as their directions may be significantly different from those on the label.

How is moxidectin + fluralaner given?

Moxidectin + fluralaner is applied topically to the skin. During the first 30 minutes after application, monitor to ensure that your pet does not lick the product. Do not apply this medication to irritated skin. Do not bathe your pet for at least four days s after application. Do not touch this area until the product is no longer noticeable.

What if I miss giving my pet the scheduled dose?

Give the dose as soon as you remember and start a new monthly dosing schedule. For example, if you forgot to give your pet his/her dose on June 1st and remember on June 18th, give the dose on June 18th and start a new schedule. The next dose your pet will receive would be on August 18th. Do not give your pet two doses at once. Contact your veterinarian if you are concerned about a missed dose.

Are there any potential side effects?

When used as directed in cats, side effects are uncommon. Side effects may include vomiting, hair loss at the application site, itching, diarrhea, lethargy, excessive drooling, and dry skin. If the product is ingested by your pet, side effects include salivation and vomiting. Fluralaner belongs to the isoxazoline class of drugs, which have been associated with tremors and seizures.

This long-acting medication is designed to work for at least eight weeks. However, negative side effects are usually short-lived if they occur at all.

Are there any risk factors for this medication?

Moxidectin + fluralaner should not be used in pets that are hypersensitive or allergic to it. Use cautiously in animals with low body fat (sick or very young), as they are more prone to side effects. Do not use this medication in sick, debilitated, or underweight cats. Use caution in cats with known neurologic disorders. Safety in breeding, pregnant, or nursing animals has not been established.

Are there any drug interactions I should be aware of?

Specific interactions with moxidectin + fluralaner have not been reported, however, benzodiazepines should be closely monitored when used with moxidectin. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.

Is there any monitoring that needs to be done with this medication?

There is no specific monitoring that needs to be done while your pet is taking this medication. Your veterinarian may monitor your pet to be sure that the medication is working.

How do I store this medication?

Moxidectin + fluralaner topical should be stored in its unopened pouch between 4°C – 25°C (39°F – 77°F).

What should I do in case of an emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

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