Fluticasone Propionate

By Lauren R. Forsythe, PharmD, MBA, DICVP; Rania Gollakner, BS, DVM, MPH

What is fluticasone propionate?

Fluticasone propionate (brand name: Flovent®) is a glucocorticoid used as an inhaled treatment for asthma or other chronic respiratory diseases involving the trachea and bronchi (airways).

Its use in cats and dogs to treat airway disease is “off label” or “extra label”. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.

How is fluticasone propionate given?

  • Fluticasone propionate is usually given as an inhaled treatment via an aerosol canister and approved delivery device (AeroDawg or AeroKat). 
  • Before using, shake well and administer this medication at room temperature. 
  • The first time the inhaler is used, and if it hasn’t been used in the previous two weeks, dispense one “primer” dose into the air before administration.
  • When ready to administer, pre-load the chamber with a puff of the medication, and immediately place snuggly over your pet’s muzzle. 
  • Allow your pet to breathe 7 to 10 times before removing the mask.
  • An acclimation and training period may be required before using the delivery device with the medication. Slowly introduce your pet to the device with positive rewards such as praise, treats, petting, etc., to encourage acceptance.

This medication should take effect within 1 to 2 hours.

What if I miss giving my pet the medication?

If you miss a dose, give the next dose as soon as you remember, and then continue with the regular dosing scheduleHowever, if it is almost time for the next scheduled dose, either skip the missed dose and resume the regular dosing schedule, or give the missed dose and then wait the recommended interval before giving the next dose (continue giving it regularly at that new time).

Never give your pet two doses at once or give extra doses.

Are there any potential side effects?

Few studies have been done in animals, but in humans, the most common side effects include inflammation and infection of the upper airway (such as a sore throat).

Contact your veterinarian if any of the following side effects occur:

  • increased thirst
  • increased urination
  • increased appetite
  • increased weight 
  • hair loss
  • weakness
  • changes to skin or coat

This short-acting medication should only last approximately 24 hours.

Are there any risk factors for this medication?

Fluticasone should NOT BE USED:

  • in pets that are hypersensitive or allergic to it
  • during an acute bronchospasm event (wheezing or shortness of breath)

Fluticasone should BE USED WITH EXTREME CAUTION in:

  • pets that are pregnant or breeding (although studies in cats and dogs are limited).

Fluticasone should be USED WITH CAUTION in:

  • pets that are lactating and nursing, as it is unknown if this medication is excreted in milk.

Are there any drug interactions I should be aware of?

The possibility of drug interactions is low, since only a small amount of the drug enters the bloodstream. However, use caution when using fluticasone with drugs that inhibit certain liver enzymes, such as ketoconazole.

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.

Is any monitoring required with this medication?

No specific monitoring is required while your pet is taking this medication. Your veterinarian may monitor your pet to be sure that the medication is working.

How do I store fluticasone propionate?

  • Fluticasone aerosol should be stored between 2°C and 20°C (36°F and 86°F). 
  • Store the canister with the mouthpiece down.
  • Protect this medication from direct sunlight and from freezing. 
  • Do not puncture the canister or expose it to heat or fire.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

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