What is imidacloprid + flumethrin?
Imidacloprid + flumethrin (Seresto® collar) is a topical antiparasitic drug contained in a collar. It is used to control fleas, ticks, and chewing lice on dogs and puppies at least 7 weeks of age and used to control fleas and ticks in cats and kittens that are at least 10 weeks of age.
How do I give my pet imidacloprid + flumethrin?
- Imidacloprid + flumethrin comes as a collar impregnated with the medication.
- Remove the collar from its package and place around the animal’s neck, securing with the buckle.
- Do not keep the collar too loose or too tight (2 fingers should fit comfortably between the collar and neck).
- Adjust the fit as needed in growing puppies and kittens.
- The collar should be worn for the entire 8 months.
- Do not allow this medication to touch the eyes or mouth.
- The collar is water-resistant. However, avoid bathing and swimming more than once per month to ensure the collar remains effective for the full 8 months.
- Ensure the labeled product is used for the correct species (i.e., do not use the dog collar on cats).
This medication will start to take effect in 24 hours and the effects will last up to 8 months if the product is used properly.
Follow your veterinarian’s instructions and do not apply more than 1 collar to the pet at once. Contact your veterinarian if you are concerned about the collar’s effectiveness.
Are there any potential side effects?
Imidacloprid + flumethrin may cause the following side effects:
- Redness, itching, or irritation at site of application
- Mild fur loss
Serious adverse reactions may occur. If any of the following signs develop, stop giving imidacloprid + flumethrin and contact your veterinarian immediately:
- An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment and notify your veterinarian if you have any concerns.
Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This long-acting medication lasts for several months, although effects can be longer in pets with liver or kidney disease.
Are there any risk factors for this medication?
DO NOT USE imidacloprid + flumethrin in:
- Pets that are taking other flea and tick preventives
USE WITH CAUTION in:
- Pets that are allergic to any component
- Pets that are sick or weak
- Pets that are pregnant, nursing, or used for breeding
- Pets that are younger than the labeled age range
Are there any drug interactions I should be aware of?
Certain medications should be USED WITH CAUTION when given with imidacloprid + flumethrin, including:
- Other medications used for flea and tick prevention
Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.
Is any monitoring needed with this medication?
- Your veterinarian will let you know when and how they want to reassess your pet to ensure the medication is working and not causing side effects.
- At home, monitor for any side effects such as those noted above. If any occur, stop using the medication and contact your veterinarian.
How do I store imidacloprid + flumethrin?
- Store at room temperature in a cool, dry place.
- Keep medication out of reach of children and pets.
What should I do in case of emergency?
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms. Report any adverse effects to the FDA or Health Canada.
© Copyright 2026 LifeLearn Inc. This content was written by LifeLearn Animal Health (LifeLearn Inc.) and is licensed to this practice for the personal use of its clients. Copying, printing, or further distributing this material is prohibited without LifeLearn’s express written consent. The use of artificial intelligence or automated tools to rewrite, republish, adapt, or repurpose this content, in whole or in part, is prohibited and does not create any ownership or derivative rights. This content does not contain all available information about medications and has not been reviewed by the FDA’s Center for Veterinary Medicine or Health Canada’s Veterinary Drugs Directorate. This content is not a substitute for medical advice or a proper clinical examination. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Last updated on Jul 10, 2026. |