Acetic Acid + Boric Acid Otic

Lauren R. Forsythe, PharmD, MBA, DICVP; Kayla Hyland, DVM

What is acetic acid + boric acid otic?

Acetic acid + boric acid otic (brand name Malacetic Otic®) is an antibacterial and antifungal medication used as an ear cleaner and drying agent in dogs and cats with ear infections. It may be used in other species.

This cleanser may be part of a combination product that includes other medications like ketoconazole, chlorhexidine, or a steroid. This medication is available over the counter (OTC) but should only be used under the direction of a veterinarian.

The U.S. Food and Drug Administration (FDA) does not review veterinary health products (e.g., shampoos, cleansers, topical products) for safety or effectiveness before they are sold to the public. Manufacturers of veterinary health products must ensure their products are safe and labeled accurately.

The FDA requires that these products contain a disclaimer that says, “This product is not intended to diagnose, treat, cure or prevent any disease.” Health Canada licenses “veterinary health products” after reviewing safety, efficacy, and manufacturing information provided by the manufacturer. These products are not tested by Health Canada.

Your veterinarian is the best source of information about the safety of veterinary health products in pets. These products can also have side effects, like pharmaceuticals. Although the information in this handout may be helpful, it also may be incomplete and may not represent the full range of effects this product could have on your pet. Follow your veterinarian’s directions and cautions carefully and report any concerns to them.

How do I give my pet acetic acid + boric acid otic?

  • This cleanser is used in the ear canal.
  • Shake well before applying into the ear.
  • Follow your veterinarian’s directions regarding the frequency of doses and the appropriate sequence of ear medications in relation to this cleanser.
  • Avoid contact with eyes.
  • Wash hands after use.
 

What if I miss giving my pet the medication?

If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.

Are there any potential side effects?

Acetic acid + boric acid otic may cause the following side effects:

  • Worsening irritation or reddening of the ear or surrounding skin
 

The following reactions are extremely rare; if they occur, contact your veterinarian immediately:

  • An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
 

Drug sensitivities can develop over time, with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment and notify your veterinarian if you have any concerns. Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately.

Are there any risk factors for this medication?

DO NOT USE acetic acid + boric acid otic in:

  • Pets that are allergic to any component
  • Pets that are immature
  • Pets that pregnant or nursing
  • Pets with severely irritated skin or ears
 

Are there any drug interactions I should be aware of?

No drug interactions have been reported for this cleanser; however, using this cleanser soon before or after ear medication may reduce its effectiveness. Your veterinarian will tell you how close together you can give these treatments.

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

  • Your veterinarian will let you know when and how they want to reassess your pet to ensure the medication is working and not causing side effects.
  • At home, monitor for any side effects such as those noted above. If any occur, stop using the medication and contact your veterinarian.
 

How do I store acetic acid + boric acid otic?

  • Store the medication in its original container, at room temperature, with a tightly closed cap.
  • Protect from light and moisture.
  • Do not freeze.
  • Keep medication out of reach of children and pets.
 

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms.

© Copyright 2026 LifeLearn Inc. Used and/or modified with permission under license.

Related Articles