Fenofibrate

What is fenofibrate?

Fenofibrate is a medication used to lower triglyceride levels (a type of fat or lipid) in dogs. Its use in cats and other animals has not been studied.  It is used off label (extra label) in veterinary medicine. Many drugs are commonly prescribed for off-label use in veterinary medicine.

“Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.

How do I give my pet fenofibrate?

• Fenofibrate comes in capsule and tablet forms. Both forms are given orally (by mouth).
• Fenofibrate comes in many formulations that may not be equally effective – confirm with your veterinarian that you are using the appropriate formulation.
• This medication is given with food, usually the first meal of the day.
• Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears that your pet is feeling better.

This medication should take effect within a few hours, although outward effects may not be noticeable. 

What if I miss giving my pet the medication?

If you miss a dose, give it as soon as you remember, and then wait the recommended time for the next dose, as prescribed by your veterinarian. Do not give the pet two doses at once.

Are there any potential side effects from fenofibrate?

Fenofibrate may cause the following side effects:

• Flatulence 
• Diarrhea
• Loss of appetite
• Nausea

Serious adverse reactions may occur. If any of the following signs develop, stop giving fenofibrate and contact your veterinarian immediately:

• An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment and notify your veterinarian if you have any concerns. 

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24 hours, although effects may last longer in pets with kidney or liver disease. 

Are there any risk factors for this medication?

DO NOT USE fenofibrate in:

• Pets that are allergic to any component of the medication
• Pets with liver disease or gallbladder disease

USE WITH CAUTION in:

• Pets with kidney disease, diabetes mellitus, or hypothyroidism
• Pets that are geriatric
• Pets that are nursing

Are there any drug interactions I should be aware of?

Certain medications should be USED WITH CAUTION when given with fenofibrate, including:

• Cannabidiol
• Cholestyramine
• Colchicine
• Cyclosporine
• Glipizide
• Mycophenolate
• Omeprazole
• Statins (e.g., lovastatin)
• Ursodiol

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

• Your veterinarian will assess fasted baseline blood work (including cholesterol and triglycerides) before starting this medication.
• Your veterinarian will let you know when and how they want to reassess your pet to ensure the medication is working and not causing side effects.
• At home, monitor for any side effects such as those noted above. If any occur, stop using the medication and contact your veterinarian. 

How do I store fenofibrate?

• Store at room temperature of 77°F (25°C), with excursions permitted between 59°F and 86°F (15°C and 30°C).
• Protect from light and moisture.
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms. Report any adverse effects to the FDA or Health Canada.