What is imidacloprid and pyriproxyfen?
Imidacloprid and pyriproxyfen (brand names Advantage®II, Advantage Plus®, Provecta®II) is a topical (spot-on) antiparasitic drug used to repel and kill fleas and lice in dogs and puppies that are at least 7 weeks of age and weigh at least 1.36 kg (3 lb). This medication is labeled for treatment of flea infestations in cats and kittens that are at least 7–8 weeks of age and weigh at least 0.9 kg (2 lb) or 2.3kg (5 lb), depending on the product.
Certain products may be labeled for use in ferrets or rabbits or may be used “off label” or “extra label”. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions carefully.
Do not confuse this medication with K9 Advantix®II, Provecta® Advanced, or Activate®II, similar products labeled for use in dogs only, as those medications contain permethrin, which is toxic to cats.
How do I give my pet imidacloprid and pyriproxyfen?
Imidacloprid and pyriproxyfen comes in topical solution form.
- Topical solutions are applied directly onto the skin. Part the fur at the base of the head and apply the product directly to visible skin as per manufacturer instructions.
- Do not apply to broken skin or wet fur.
- Do not allow animals to lick or groom the application site for several days after application.
- Do not allow this medication to touch the eyes or mouth.
- Humans should avoid direct contact with the application site for 24 hours after this medication is applied.
This medication will start to take effect in a few hours and the effects will last several weeks.
What if I miss giving my pet the medication?
If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.
Are there any potential side effects from imidacloprid and pyriproxyfen?
Imidacloprid and pyriproxyfen may cause the following side effects:
- redness, itching, or irritation at site of application
- drooling
- vomiting, diarrhea
- unusual behavior
The following reactions are rare, but if they occur, contact your veterinarian immediately:
- an allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment. Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This long-acting medication lasts for several weeks, although effects can be longer in pets with liver or kidney disease.
Are there any risk factors for this medication?
This medication should NOT BE USED in animals who are:
- allergic to any component
- younger than the labeled age and weight ranges
This medication should be used with CAUTION in pets who are:
- sick or weak
- pregnant, nursing, or used for breeding
- taking other flea and tick preventatives
Are there any drug interactions I should be aware of?
Certain medications should be USED WITH CAUTION when given with imidacloprid and pyriproxyfen, including:
- other medications used for flea and tick prevention
Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.
Is any monitoring needed with this medication?
Your veterinarian may schedule follow-up visits for monitoring. In this case, follow your veterinarian’s directions.
How do I store imidacloprid and pyriproxyfen?
- Store at room temperature in a cool, dry place.
- Protect from freezing.
- Keep medication out of reach of children and pets.
What should I do in case of emergency?
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.
