Isoflupredone Combinations Topical

What are isoflupredone combinations topical?

Isoflupredone combinations topical are combination medications containing isoflupredone (a corticosteroid) and other medications. Isoflupredone may be combined with an antibiotic, a local anesthetic, or other medications to treat surface skin conditions where use of a steroid combination product is indicated.

Its use may be off label (extra label) depending on the species, conditions being treated, and formulation. Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. 

In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.

How do I give my pet isoflupredone combinations topical?

• Isoflupredone combinations come in powder and ointment forms, often compounded.
• All forms are applied topically, directly on the skin.
• Clean the affected area as directed by your veterinarian before applying the medication.
• Do not allow the tip of the bottle to touch affected areas.
• Wash your hands after application and avoid contact with your eyes, mouth, and nose.
• Do not let your pet lick or groom the affected area for at least 30 minutes after application.
• Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears your pet is feeling better.

What if I miss giving my pet the medication?

If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.

Are there any potential side effects?

Isoflupredone combinations topical may cause the following side effects:

• Redness and/or swelling at site of application
• Thinning of fur or fur loss

Isoflupredone combinations topical may cause the following side effects if it is used over a large area of the body or ingested through licking:

• Decreased energy level or appetite, vomiting, diarrhea
• Increased thirst  

Serious adverse reactions may occur. If any of the following signs develop, stop giving isoflupredone combinations topical and contact your veterinarian immediately:

• An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment and notify your veterinarian if you have any concerns.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This moderate-acting medication should stop working within a few days, although effects may last longer in pets with liver or kidney disease. Effects may also last longer depending on the medications in the combination product.

Are there any risk factors for this medication?

DO NOT USE isoflupredone combinations topical in:

• Pets that are allergic to any component
• Pets with tuberculosis skin infections

USE WITH CAUTION in:

• Pets that have a small body size
• Pets that need treatment of large areas
• Pets that are pregnant or nursing

Are there any drug interactions I should be aware of?

There are no documented drug interactions for this medication, although certain medications may interact with the individual drugs in a combination medication. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

• Your veterinarian will let you know when and how they want to reassess your pet to ensure the medication is working and not causing side effects.
• At home, monitor for any side effects such as those noted above. If any occur, stop using the medication and contact your veterinarian. 

How do I store isoflupredone combinations topical?

• Store the medication in its original container, protected from moisture, at room temperature.
• Keep the cap tightly closed.
• Store compounded forms of this medication according to the label.
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms. Report any adverse effects to the FDA or Health Canada.