Mupirocin Topical

By Kayla Hyland, DVM

What is mupirocin topical?

Mupirocin topical, also known as pseudomonic acid A (brand names Muricin®, Bactroban®, Centany®), is an antibiotic used to treat skin infections. It is labeled for use in dogs to treat skin infections caused by susceptible strains of Staphlococcus and other gram-positive bacteria.

It is used “off label” or “extra label” to treat skin infections in other species and acne in cats. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully.

How do I give my pet mupirocin topical?

Mupirocin topical comes in cream and ointment forms.

  • Creams and ointments are given topically on the skin. 
  • Clean the affected area as directed by your veterinarian before applying the medication. 
  • Do not let your pet lick or chew at the area for at least 20 to 30 minutes after applying. This medication needs 10 minutes of contact time with the affected area for it to be effective.
  • Wash your hands after application and avoid contact with eyes.
  • Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears that your pet is feeling better.

What if I miss giving my pet the medication?

Give the missed dose as soon as you remember and then continue with the regular dosing schedule. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give the pet two doses at once.

Are there any potential side effects from mupirocin topical?

Mupirocin topical may cause the following side effects:

  • redness, itching, and/or pain at site of application
  • decreased energy level or appetite
  • increased thirst or urination
  • worsening of the skin issue

The following reactions are rare, but if they occur, contact your veterinarian immediately:

  • an allergic reaction such as irregular breathing, rash, fever, or puffiness and swelling around the face

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24 hours.

Are there any risk factors for this medication?

AVOID this medication in animals allergic to any of the components or allergic to polyethylene glycol.

Use with CAUTION when treating deep, extensive skin wounds and in pets that are pregnant or breeding.

Are there any drug interactions I should be aware of?

No known drug interactions have been reported.

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

Your veterinarian may schedule a follow-up visit after the course of medication is complete to ensure the infection has been cleared and/or do additional testing to ensure this is the right medication for the type of infection that is present. In this case, follow your veterinarian’s directions.

How do I store mupirocin topical?

  • Store the medication in its original container, protected from light, at room temperature. 
  • Keep the cap tightly closed.
  • If your veterinarian or pharmacist has made a special (compounded) formulation for your pet, follow their storage recommendations and expiration date for the product.
  • Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

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