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Emi Ohashi

DVM, PhD, DACVIM (Oncology)
Veterinary Specialist
Availability: Tuesday, Wednesday, Friday & Saturday

At a Glance

Practicing Since:


Board Certified:


Specialties Include:

Stem cell tumor
Molecular targeted therapy
Integrative oncology

Dr Ohashi's main focus is developing treatments that are personalized and improve a patient’s quality of life to allow them more time at home with their loved-ones.

In her spare time, Dr. Ohashi loves spending time with her husband, two dogs and two cats. She also enjoys hiking, exploring new restaurants, and travel when she can.
Papers Authored
A Primary Rectal Lymphoma in a Spayed Chinese Crested
Authored: Ohashi E
Published: Pulse Magazine (The Official Publication of the Southern California Veterinary Medical Association). 2015 Aug; 19-20
Nosocomial Outbreak of Serious Canine Infectious Tracheobronchitis (Kennel Cough) Caused by Canine Herpesvirus Infection
Abstract: Canine herpesvirus (CHV; Canid herpesvirus 1) is principally a perinatal pathogen of pregnant bitches and newborn pups and secondarily a respiratory tract pathogen of older pups and dogs. Infectious disease of the canine respiratory tract frequently occurs among dogs in groups, in which it is called “ infectious tracheobronchitis” (ITB). Mortality from ITB is generally negligible, and the clinical importance of CHV as an ITB pathogen is considered to be low. The present report describes a novel ITB outbreak accompanied by death among aged dogs in an animal medical center. Most inpatient dogs had received medications that could induce immunosuppression. 
Authored: Kawakami K, Ogawa H, Maeda K, Imai A, Ohashi E, Matsunaga S, Tohya Y, Ohshima T, Mochizuki M
Published: J Clin Microbiol. 2010
Activation of the PI3 Kinase Pathway by Retinoic Acid Mediates sodium/iodide Symporter Induction and Iodide Transport in MCF-7 Breast Cancer Cells
Abstract: Iodide uptake in the thyroid and breast is mediated by the sodium/iodide symporter (NIS). NIS activation is used for radioiodide imaging and therapeutic ablation of thyroid carcinoma. NIS is expressed in >70% of breast cancers but at a level insufficient for radioiodine treatment. All-trans retinoic acid (tRA) induces NIS gene expression and functional iodide uptake in human breast cancer cell lines and mouse breast cancer models. tRA usually regulates gene expression by direct interaction of RA receptor (RAR) with a target gene, but it can also act through nongenomic pathways. We report a direct influence of tRA treatment on the phosphoinositide 3-kinase (PI3K) signal transduction pathway that mediates tRA-induced NIS expression in MCF-7 breast cancer cells. 
Authored:  Ohashi E, Kogai T, Kagechika H, Brent GA
Published: Cancer Res. 69: 3443-3450. 2009
Retinoic Acid Stimulation of the sodium/iodide Symporter in MCF-7 Breast Cancer Cells Is Mediated by the Insulin Growth factor-I/phosphatidylinositol 3-kinase and p38 Mitogen-Activated Protein Kinase Signaling Pathways
Objective: The objective of this work was to study the relative role of genomic and nongenomic pathways in tRA stimulation of NIS expression in MCF-7 cells.
Authored:  Kogai T, Ohashi E, Jakobs MS, Sajid-Crochett S, Fisher ML, Kanamoto Y, Brnt GA
Published: J Clin Endocrinol Metab. 93: 1884-1892, 2008
Role of beta1 Integrins in Adhesion of Canine Mastocytoma Cells to Extracellular Matrix Proteins
Abstract:  The interactions of tumor cells with the extracellular matrix (ECM) are a crucial step in invasion and metastasis. Integrins are adhesive molecules forming heterodimers with alpha and beta subunits that play a definitive role in these interactions. In this study, mastocytoma (mast cell tumor: MCT) cell-ECM interaction was investigated using 3 canine MCT cell lines: CM-MC (originating from cutaneous MCT), VI-MC (originating from intestinal MCT), and CoMS (originating from oral MCT).
Authored: Takahashi T, Ohashi E, Nakagawa T, Mochizuki M, Nishimura R, Sasaki N.
Published: J Vet Med Sci. 69: 495-499, 2007
Cyclopedic Protein Expression Analysis of Cultured Canine Mammary Gland Adenocarcinoma Cells From Six Tumours
Abstract: We characterised cultured canine mammary gland adenocarcinoma cells by exhaustive step protein expression analysis to identify factors associated with tumour progression or metastasis of canine mammary gland tumour. Cultured adenocarcinoma cells derived from a total of 3 primary and 3 metastatic lesions from 3 dogs (CHMp/m, CIPp/m and CNMp/m, where CHM, CIP, and CNM indicate the 3 animals) were used in this study.
Authored: Nakagawa T, Watanabe M, Ohashi E, Uyama R, Takauji S, Mochizuki M, Nishimura R, Ogawa H,Sugano S, and Sasaki, N
Published: Res Vet Sci. 80: 317–323, 2006
Retinoids Induce Growth Inhibition and Apoptosis in Mast Cell Tumor Cell Lines
Abstract: Retinoids are well recognized as promising antitumor agents in humans. However, there have only been a few reports about the effect of retinoids in canine cancers. To investigate the antitumor effect of retinoids on mast cell tumors (MCT), inhibitory effect on cell growth and induction of apoptosis were examined in vitro. 
Authored: Ohashi E, Miyajima N, Nakagawa T, Takahashi T, Kagechika H, Mochizuki M, Nishimura R, and Sasaki N
Published: J Vet Med Sci. 68: 797-802, 2006
See our departments


Cancer can be one of the most complex and difficult diseases to diagnose and treat, not to mention emotionally draining on every level for both you and your pet. Our oncology department leads the attack against your pet’s cancer, coming at it from all sides with traditional therapies, surgery, chemotherapy, immunotherapy and chemotherapy to provide...
VCA Animal Specialty Group

4641 Colorado Blvd.

Los Angeles, CA 90039

Main: 818-244-7977

Fax: 818-507-9418

Hospital Hours:

    Mon-Sun: Open 24 hours

Specialty Appointment Hours:

Mon-Sun: Please Call For An Appointment

Emergency Hours:

Mon-Sun: Open 24 hours

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