Authored: Ohashi E
Published: Pulse Magazine (The Official Publication of the Southern California Veterinary Medical Association). 2015 Aug; 19-20

Abstract: Canine herpesvirus (CHV; Canid herpesvirus 1) is principally a perinatal pathogen of pregnant bitches and newborn pups and secondarily a respiratory tract pathogen of older pups and dogs. Infectious disease of the canine respiratory tract frequently occurs among dogs in groups, in which it is called “ infectious tracheobronchitis” (ITB). Mortality from ITB is generally negligible, and the clinical importance of CHV as an ITB pathogen is considered to be low. The present report describes a novel ITB outbreak accompanied by death among aged dogs in an animal medical center. Most inpatient dogs had received medications that could induce immunosuppression. 
Authored: Kawakami K, Ogawa H, Maeda K, Imai A, Ohashi E, Matsunaga S, Tohya Y, Ohshima T, Mochizuki M
Published: J Clin Microbiol. 2010

Abstract: Iodide uptake in the thyroid and breast is mediated by the sodium/iodide symporter (NIS). NIS activation is used for radioiodide imaging and therapeutic ablation of thyroid carcinoma. NIS is expressed in >70% of breast cancers but at a level insufficient for radioiodine treatment. All-trans retinoic acid (tRA) induces NIS gene expression and functional iodide uptake in human breast cancer cell lines and mouse breast cancer models. tRA usually regulates gene expression by direct interaction of RA receptor (RAR) with a target gene, but it can also act through nongenomic pathways. We report a direct influence of tRA treatment on the phosphoinositide 3-kinase (PI3K) signal transduction pathway that mediates tRA-induced NIS expression in MCF-7 breast cancer cells. 
Authored:  Ohashi E, Kogai T, Kagechika H, Brent GA
Published: Cancer Res. 69: 3443-3450. 2009

Objective: The objective of this work was to study the relative role of genomic and nongenomic pathways in tRA stimulation of NIS expression in MCF-7 cells.
Authored:  Kogai T, Ohashi E, Jakobs MS, Sajid-Crochett S, Fisher ML, Kanamoto Y, Brnt GA
Published: J Clin Endocrinol Metab. 93: 1884-1892, 2008

Abstract:  The interactions of tumor cells with the extracellular matrix (ECM) are a crucial step in invasion and metastasis. Integrins are adhesive molecules forming heterodimers with alpha and beta subunits that play a definitive role in these interactions. In this study, mastocytoma (mast cell tumor: MCT) cell-ECM interaction was investigated using 3 canine MCT cell lines: CM-MC (originating from cutaneous MCT), VI-MC (originating from intestinal MCT), and CoMS (originating from oral MCT).
Authored: Takahashi T, Ohashi E, Nakagawa T, Mochizuki M, Nishimura R, Sasaki N.
Published: J Vet Med Sci. 69: 495-499, 2007

Abstract: We characterised cultured canine mammary gland adenocarcinoma cells by exhaustive step protein expression analysis to identify factors associated with tumour progression or metastasis of canine mammary gland tumour. Cultured adenocarcinoma cells derived from a total of 3 primary and 3 metastatic lesions from 3 dogs (CHMp/m, CIPp/m and CNMp/m, where CHM, CIP, and CNM indicate the 3 animals) were used in this study.
Authored: Nakagawa T, Watanabe M, Ohashi E, Uyama R, Takauji S, Mochizuki M, Nishimura R, Ogawa H,Sugano S, and Sasaki, N
Published: Res Vet Sci. 80: 317–323, 2006

Abstract: Retinoids are well recognized as promising antitumor agents in humans. However, there have only been a few reports about the effect of retinoids in canine cancers. To investigate the antitumor effect of retinoids on mast cell tumors (MCT), inhibitory effect on cell growth and induction of apoptosis were examined in vitro. 
Authored: Ohashi E, Miyajima N, Nakagawa T, Takahashi T, Kagechika H, Mochizuki M, Nishimura R, and Sasaki N
Published: J Vet Med Sci. 68: 797-802, 2006